Professor of Clinical Pediatrics, in the Division of Endocrinology Director of the Weight Assessment for Teen and Child Health (WATCH) Program at UCSF.
Dr. Lustig is a nationally recognized authority in the field of neuroendocrinology, with a specific emphasis on the regulation of energy balance by the central nervous system. He is currently investigating the contribution of biochemical, neural, hormonal, and genetic influences in the expression of the current obesity epidemic both in children and adults. He has defined a syndrome of vagally mediated beta-cell hyperactivity which leads to insulin hyper secretion and obesity, and which is treatable by insulin suppression. This phenomenon may occur in up to 20% of the obese population. He is interested in the hypothalamic signal transduction of insulin and leptin, and how these two systems interact. He is studying the cardiovascular morbidity associated with hyperinsulinemia, and developing methods to evaluate and prevent this phenomenon in children. He is also analyzing the contribution of the autonomic nervous system to insulin secretion and insulin resistance in obese children, and the utility of assessing insulin dynamics in targeting obesity therapy. He has recently turned his attention to the role of fructose in generating insulin resistance, leptin resistance, increased reward, and metabolic syndrome.
Dr. Lustig graduated from MIT, and received his M.D. from Cornell University Medical College. He performed his pediatric residency at St. Louis Children's Hospital, and his clinical fellowship at UCSF. From there, he spent six years as a post-doctoral fellow in neuroendocrinology at The Rockefeller University in New York.
Dr. Lustig has authored over 85 research articles and 45 chapters. He has served on various writing committees for the Endocrine Society and the American Heart Association. He is the former Chairman of the Obesity Task Force of the Lawson Wilkins Pediatric Endocrine Society, a current member of the Obesity Task force of The Endocrine Society, and on the Steering Committee of the International Endocrine Alliance to Combat Obesity.