Jon did his doctoral work in molecular biology at MIT, in the laboratory Salvador Luria. He is the author of 15 books, currently in print in over 45 languages. His most recent is Mindfulness Meditation for Pain Relief (April 2023). He is also the author of a series of research papers on MBSR dating back to 1982. In a 2021 study of trends and developments in mindfulness research over 55 years (1966-2021), three of his empirical studies figure among the ten most cited articles on mindfulness (nos. 3, 5, and 9) in the scientific literature; and a review article he authored is number two among citations of the top ten review articles on mindfulness.

His work and that of a global community of colleagues has contributed to a growing movement of mindfulness into mainstream institutions such as medicine, psychology, health care, neuroscience, schools, higher education, business, social justice, criminal justice, prisons, the law, technology, the military, government, and professional sports. Over 700 hospitals and medical centers around the world now offer MBSR.